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Investigators noted significant correlations between the rs12721025 SNP, which had the strongest observed association with IHPS, and 50 SNPs at the locus that had been previously associated with total and/or HDL cholesterol levels. The cholesterol-lowering allele was significantly associated with increased IHPS risk for all 50 SNPs. Researchers measured the cholesterol and triglyceride levels in umbilical cord blood samples collected from 46 cases and 189 controls, and found an inverse association between total cholesterol and IHPS risk (OR=0.77; 95% CI, 0.64-0.92 per 10 mg/dL).
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